In 2018, the NMR platform was equipped with:

the Bruker 600 MHz quadruple resonance cryo-probe for fluorine applications achieves an outstanding sensitivity for the observation of ¹⁹F atoms.
This probe is installed on our 600 MHz Avance I™ Bruker spectrometer.

The addition of fluorine atoms to peptides for drugs or the substitution of ¹H by ¹⁹F has many applications in biology. Fluorine as markers is an efficient method to study interactions between drugs and proteins.

Application example

Self-organization Properties of a GPCR-Binding Peptide with a Fluorinated Tail Studied by Fluorine NMR Spectroscopy
Capucine Jourdain de Muizon, Sridévi M. Ramanoudjame, Lucie Esteoulle, Claude Ling, Germain Brou, Dr. Nicolas Anton, Thierry Vandamme, Dr. Marc-André Delsuc, Dr. Dominique Bonnet, Prof. Bruno Kieffer