Monthly Archives: June 2021

NMR platform helium recovery system

The 700 MHz spectrometer must be filled by an amount of ~560 liters of liquid helium per year, the 600 MHz needs ~320 liters/year to maintain the magnet at supraconductivity temperatures. This represents a consumption of >600 m3 of helium gas.

In October 2018, a helium recovery system has been installed beside the NMR platform in order to preserve the helium gas resource and to allow recycling of the gas into liquid helium produced by the Strasbourg University Helium Production facility – F. Hopfner.

This project was sponsored by FRISBI.

The system was provided by Girodin-Sauer and was installed by the IGBMC technical services – C.Kolb, C. Untereiner, C.Vatté, T. Zill, R. Von Scheidt, with the kind support of F. Hopfner, C. Ling.

  • High pressure helium storage rack
  • Helium gas collector balloon
  • 200 bars helium compressor

More images.

High 19F sensitivity CryoProbe

In 2018, the NMR platform was equipped with:

the Bruker 600 MHz quadruple resonance cryo-probe for fluorine applications achieves an outstanding sensitivity for the observation of 19F atoms.
This probe is installed on our 600 MHz Avance I™ Bruker spectrometer.

Bruker QCI-F CryoProbe

The addition of fluorine atoms to peptides for drugs or the substitution of 1H by 19F has many applications in biology. Fluorine as markers is an efficient method to study interactions between drugs and proteins.

Application example


Self-organization Properties of a GPCR-Binding Peptide with a Fluorinated Tail Studied by Fluorine NMR Spectroscopy
Capucine Jourdain de Muizon, Sridévi M. Ramanoudjame, Lucie Esteoulle, Claude Ling, Germain Brou, Dr. Nicolas Anton, Thierry Vandamme, Dr. Marc-André Delsuc, Dr. Dominique Bonnet, Prof. Bruno Kieffer